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An Approach to the Treatment of Children With COVID-19

Alison Boast1,2,3, Nigel Curtis1,2,3, Johanna Holschier4

  • 1Infectious Diseases and General Medicine, The Royal Children's Hospital Melbourne.

The Pediatric Infectious Disease Journal
|May 27, 2022
PubMed

Insights

Limited data exists for treating children with acute, symptomatic coronavirus disease 2019 (COVID-19). This review proposes a management strategy for pediatric COVID-19 based on current evidence and drug safety profiles.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Acute, symptomatic coronavirus disease 2019 (COVID-19) in children presents unique management challenges due to limited specific treatment guidelines.
  • Existing evidence and drug approvals provide a basis for developing pediatric-focused therapeutic strategies.

Purpose of the Study:

  • To propose a management approach for children with acute, symptomatic COVID-19.
  • To synthesize current evidence and regulatory approvals for pediatric COVID-19 treatments.
  • To inform clinical practice regarding the safe and effective management of pediatric COVID-19.

Main Methods:

  • Literature review of published evidence on pediatric COVID-19 management.
  • Analysis of medication approvals by regulatory agencies for use in children.
  • Evaluation of the known safety profiles of recommended drugs in pediatric populations.

Main Results:

  • A proposed management framework for pediatric COVID-19 is outlined.
  • The review considers evidence-based treatments and safety data relevant to children.
  • Recommendations are aligned with current drug regulatory approvals.

Conclusions:

  • A structured approach to managing pediatric COVID-19 can be developed despite data limitations.
  • Evidence-based recommendations, considering drug safety in children, are crucial for effective treatment.
  • This review provides guidance for clinicians managing acute, symptomatic COVID-19 in pediatric patients.

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