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Related Experiment Videos

Early coma in intussusception: endogenous opioid induced?

M Tenenbein, N E Wiseman

    Pediatric Emergency Care
    |March 1, 1987
    PubMed
    Summary

    Infantile intussusception can present as decreased consciousness without abdominal pain. This case suggests endogenous opioids may cause coma and miosis, masking pain and aiding diagnosis.

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    Area of Science:

    • Pediatric Gastroenterology
    • Pediatric Neurology

    Background:

    • Infantile intussusception typically presents with abdominal pain and vomiting.
    • Altered consciousness is an uncommon presentation of intussusception.

    Observation:

    • A 10-month-old male presented with coma and miosis.
    • Symptoms were reversible with naloxone, despite no exogenous opiate use.
    • Intussusception was subsequently diagnosed.

    Findings:

    • The presentation suggests a possible role for endogenous opioids in masking abdominal pain.
    • Coma and miosis may be induced by endogenous opioid activity.
    • Naloxone's effectiveness points to an opioid-mediated mechanism.

    Implications:

    • Miosis could be a valuable diagnostic clue for intussusception presenting with altered consciousness.
    • This case broadens the understanding of atypical intussusception presentations.
    • Further research into endogenous opioid effects in pediatric emergencies is warranted.

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