Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Dynamics in Living Cells

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...

Fluid Mosaic Model

Fluid Mosaic Model

Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...

Molecular Models

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.

Non-equilibrium in the Cell

Non-equilibrium in the Cell

An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...

The Fluid Mosaic Model

The Fluid Mosaic Model

The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.

Chemistry of the Cell

Chemistry of the Cell

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Predicting human mRNA isoform levels from site-specific splicing kinetics <i>in silico</i>.

bioRxiv : the preprint server for biology·2026

Same author

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes.

Protein science : a publication of the Protein Society·2026

Same author

Bringing the genetically minimal cell to life on a computer in 4D.

Cell·2026

Same author

Bringing the genetically minimal cell to life on a computer in 4D.

Cell·2026

Same author

Spatiotemporal 4D Whole-cell Modeling of a Minimal Autotroph Reveals Central Carbon Metabolism Regulated Locally by Protein Megacomplexes via Post-translational ModiBications under Light Disturbance.

bioRxiv : the preprint server for biology·2026

Same author

Assembly of Macromolecular Complexes in the Whole-Cell Model of a Minimal Cell.

The journal of physical chemistry. B·2025

Search research articles

Related Experiment Video

Updated: Sep 21, 2025

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Integrating cellular and molecular structures and dynamics into whole-cell models.

Zaida Luthey-Schulten¹, Zane R Thornburg², Benjamin R Gilbert²

¹Department of Chemistry, University of Illinois at Urbana-Champaign, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USA; Center for the Physics of the Living Cell, University of Illinois at Urbana-Champaign, USA.

Current Opinion in Structural Biology

|May 27, 2022

Summary

Creating a dynamical whole-cell model (DWCM) requires detailed cell data over time. This review explores challenges in gathering information for bacterial DWCMs.

More Related Videos

Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Related Experiment Videos

Last Updated: Sep 21, 2025

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Area of Science:

Cell biology
Systems biology
Computational biology

Background:

Understanding cellular dynamics requires data on size, shape, components, reactions, and environmental interactions over time.
Integrating vast experimental data necessitates theoretical models and simulations.

Purpose of the Study:

To review current challenges and problems in developing dynamical whole-cell models (DWCMs).
Focus on simple, well-studied bacterial systems.

Main Methods:

Literature review of existing research on cellular modeling.
Analysis of data requirements for dynamical whole-cell models.

Main Results:

Significant progress is being made across various fronts in cell modeling.
Specific challenges exist in obtaining comprehensive data for all aspects of DWCMs.

Conclusions:

Developing comprehensive dynamical whole-cell models for bacteria is complex.
Further research is needed to overcome data acquisition and integration challenges.