Evaluation of applying space-variant resolution modeling to attenuation correction in PET

Attenuation correction aims to recover the underestimated tracer uptake and improve the image contrast recovery in positron emission tomography (PET). However, traditional ray-tracing-based projection of attenuation maps is inaccurate as some physical effects are not considered, such as finite crystal size, inter-crystal penetration and inter-crystal scatter. In this study, we evaluated the effects of applying resolution modeling (RM) to attenuation correction by implementing space-variant RM to complement physical effects which are usually omitted in the traditional projection model. We verified this method on a brain PET scanner developed by our group, in both Monte Carlo simulation and real-world data, in comparison with space-invariant Gaussian RM, average-depth-of-interaction, and multi-ray tracing methods. The results indicate that the space-variant RM is superior in terms of artifacts reduction and contrast recovery.