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Can animal models resemble a premenstrual dysphoric condition?
Estrada-Camarena Erika1, Carolina López-Rubalcava2
1Laboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz." Mexico City, México.
Frontiers in Neuroendocrinology
|May 27, 2022
Summary
Premenstrual disorders (PMD) affect many women, with severe forms classified as premenstrual dysphoric disorder (PMDD). This review examines factors influencing PMD and animal models for studying PMDD mechanisms and treatments.
Area of Science:
- Reproductive endocrinology and psychiatry.
Background:
- Premenstrual disorders (PMD) are common, affecting up to 80% of women, with severe forms including premenstrual dysphoric disorder (PMDD) characterized by psychiatric symptoms.
- PMDD significantly impacts quality of life for 3-8% of women, necessitating further research into its complex etiology.
Purpose of the Study:
- To review factors associated with PMD, focusing on the Hypothalamus-Pituitary-Ovarian (HPO) and Hypothalamus-Pituitary-Adrenal (HPA) axes.
- To discuss current animal models used for studying PMDD and identify potential areas for developing new therapeutic strategies.
Main Methods:
- Literature review analyzing factors contributing to PMD.
- Examination of existing animal models for premenstrual dysphoric disorder research.
Main Results:
- Ovarian hormones play a crucial role in PMDD symptoms, with potential alterations in their synthesis, metabolism, and target sites.
- The complexity of PMDD involves multiple factors, requiring careful consideration in animal modeling.
Conclusions:
- Understanding the intricate factors of PMDD is essential for accurate animal modeling.
- Identifying key regulatory points in hormone pathways offers opportunities for novel PMDD treatment approaches.
