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Published on: February 2, 2017
Weight excess association with severity in children and adolescents with COVID-19: A systematic review
Mayara Luíza Oliveira da Silva Kist1, Gabriela Rupp Hanzen Andrades1, Caroline Abud Drumond Costa2
1Post Graduate Program in Pediatrics and Child Health of PUCRS - Pontifical Catholic University of Rio Grande do Sul, Av. Ipiranga, 6681 - Partenon, Porto Alegre, 90619-900, RS, Brazil.
Insights
Childhood obesity is a growing concern, and its link to severe COVID-19 outcomes in pediatric patients requires more research. Current studies show limited evidence of obesity as a prognostic factor for worse COVID-19 evolution in children.
Area of Science:
- Pediatric Infectious Diseases
- Public Health & Epidemiology
- Pediatric Endocrinology
Background:
- Childhood obesity is a significant public health issue, paralleling the COVID-19 pandemic.
- Adult studies indicate obesity is an independent risk factor for severe COVID-19.
- Limited research exists on the impact of excess weight on COVID-19 severity in children.
Purpose of the Study:
- To systematically review the existing literature on the relationship between excess weight and COVID-19 severity in children and adolescents.
Main Methods:
- Systematic literature review adhering to PRISMA standards.
- Searched multiple databases (PubMed, Embase, Scopus, Cochrane, Web of Science, BVS/LILACS, SciELO) in September 2020.
- Included 11 studies after screening 667 articles; assessed quality using the Newcastle-Ottawa Scale.
Main Results:
- Only 5 of the included studies specifically examined obesity's relation to adverse COVID-19 outcomes.
- Out of these 5 studies, only one demonstrated obesity as a prognostic factor for worse COVID-19 progression in pediatric patients.
- Most included studies were unicentric and from the USA; 8 achieved high-quality scores.
Conclusions:
- There is a scarcity of research investigating the association between excess weight and severe COVID-19 outcomes in pediatric populations.
- Given the established link in adults, further investigation into this relationship in children and adolescents is warranted.
Background & Aims:
Concomitantly to the coronavirus disease 2019 (COVID-19), in the child population there was already another pandemic wave in progress: childhood obesity. Numerous studies in adults have been carried out and describe obesity as an independent risk and prognostic factor for the severity of COVID-19. This study aims to systematically review the literature on the relation between weight excess and the severity of COVID-19 in children and adolescents.
Methods:
This systematic review was developed following the PRISMA standards (Preferred Reporting Items for Systematic Review and Meta-Analysis). The literature search was performed in September 2020, in the following databases: MEDLINE (via PubMed), Embase, Scopus, The Cochrane Library (Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials (CENTRAL)), Web of Science, BVS/LILACS and SciELO. Registration on the PROSPERO platform (International Prospective Registry of Systematic Reviews) can be found under the registration number: CRD42021230686.
Results:
Of the 667 selected articles, 11 were included according to all agreed criteria, most of them being unicentric and American. In assessing the risk of bias and quality, following the criteria of the Newcastle-Ottawa Scale, eight studies achieved scores higher than 7. Only 5 studies sought to assess obesity and its relation with worse outcomes (such as need for pediatric intensive care unit (PICU), mechanical ventilation (MV), tracheostomy, hospital readmission and mortality), and out of these, only one article demonstrated this comorbidity as a prognostic factor for worse evolution of the COVID picture.
Conclusions:
Few studies in the literature seek to assess excess weight and its relation with worse outcomes of COVID-19 in children and adolescents. Taking into account that there is already scientific evidence on this subject in adult patients, it is necessary to carry out more research in the pediatric age group.
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