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Association between 25-hydroxyvitamin D levels and COVID-19 severity.
Tomoki Takase1, Naoko Tsugawa2, Takayuki Sugiyama1
1Department of Pharmacy, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Clinical Nutrition ESPEN
|May 27, 2022
Summary
Low vitamin D levels are linked to severe COVID-19 outcomes in Japanese patients. This study identified low 25-hydroxyvitamin D [25(OH)D] as an independent risk factor for invasive mechanical ventilation or death.
Area of Science:
- Endocrinology
- Infectious Diseases
- Public Health
Background:
- The impact of vitamin D status on COVID-19 severity is debated.
- Few studies have investigated this association in Japanese populations.
Purpose of the Study:
- To investigate the association between 25-hydroxyvitamin D [25(OH)D] levels and COVID-19 severity in Japanese patients.
Main Methods:
- Retrospective observational study of 117 COVID-19 patients.
- Serum 25(OH)D levels measured within 5 days of admission using liquid chromatography-tandem mass spectrometry.
Main Results:
- 25(OH)D deficiency was prevalent, with 17.9% severe deficiency (<10 ng/mL) and 62.4% deficiency (10-<20 ng/mL).
- Lower serum 25(OH)D levels were significantly associated with invasive mechanical ventilation (IMV) or death (multivariate OR 1.22, p=0.005).
- A cut-off value of 10.4 ng/mL for serum 25(OH)D predicted the need for IMV or death.
Conclusions:
- This is the first study to assess vitamin D status and COVID-19 severity in Japanese patients.
- Low serum 25(OH)D levels are an independent risk factor for severe COVID-19 in this population.
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