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Histone functions as a cell-surface receptor for AGEs.

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Advanced glycation end products (AGEs) bind to cell-surface histone, regulating inflammation. This suggests AGEs may also play a role in the body's natural healing and maintenance processes.

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Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Background:

  • Advanced glycation end products (AGEs) form from sugar-protein reactions and are linked to disease.
  • The precise biological functions of AGEs, beyond their pathogenic roles, are not fully understood.

Purpose of the Study:

  • To investigate the intrinsic function of AGEs and their interactions with cellular components.
  • To identify potential receptors for AGEs on the cell surface.

Main Methods:

  • Utilized biochemical assays to demonstrate the binding of AGEs to histone.
  • Investigated the functional consequences of AGE-histone interaction on cell signaling and recruitment.

Main Results:

  • Provided evidence that AGEs specifically bind to cell-surface histone, acting as an AGE-binding protein.
  • Demonstrated that histone functions as a plasminogen receptor, and AGE binding modulates this function.
  • Showed that AGE-histone interactions regulate the recruitment of monocytes/macrophages to inflammatory sites.

Conclusions:

  • Histone acts as a cell-surface receptor for AGEs.
  • AGEs may participate in homeostatic responses by binding to histone, in addition to their known pro-inflammatory roles.