Related Experiment Video

Updated: Sep 21, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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Dysregulation and therapeutic targeting of RNA splicing in cancer

Robert F Stanley1, Omar Abdel-Wahab2

  • 1Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature Cancer
|May 27, 2022
PubMed

Insights

Cancer research reveals widespread RNA splicing errors driving tumor development. Understanding these splicing alterations offers new therapeutic strategies for various cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Aberrant RNA splicing is increasingly recognized as a hallmark of cancer.
  • Genomic alterations and disrupted splicing factors contribute to cancer-specific splicing changes.
  • These changes can affect gene expression and produce novel proteins.

Purpose of the Study:

  • To review recent advances in understanding aberrant RNA splicing in cancer.
  • To explore therapeutic strategies targeting cancer-specific splicing.

Main Methods:

  • Review of current literature on cancer splicing.
  • Analysis of high-throughput sequencing data.
  • Functional characterization of splicing alterations.

Main Results:

  • High-throughput sequencing identifies widespread, cancer-specific splicing dysregulation.
  • Aberrant splicing impacts gene expression and protein products in tumors.
  • Novel splicing-derived proteins can arise from these alterations.

Conclusions:

  • Aberrant RNA splicing is a critical factor in cancer pathogenesis.
  • Targeting cancer-specific splicing represents a promising therapeutic avenue.

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