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Sphenoid wing meningiomas: peritumoral brain edema as a prognostic factor in surgical outcome

Abdalrahman Nassar1, Volodymyr Smolanka2, Andriy Smolanka2

  • 1Uzhhorod Regional Center of Neurosurgery and Neurology, Uzhhorod National University, Uzhhorod, Ukraine. dr.abed.r.nassar@hotmail.com.

Neurosurgical Review
|May 27, 2022
PubMed

Insights

Peritumoral brain edema (PTBE) is a significant risk factor for immediate surgical outcomes in sphenoid wing meningioma patients. While PTBE negatively impacts early quality of life, its long-term effects on outcomes are not significant.

Area of Science:

  • Neurosurgery
  • Neurology
  • Oncology

Background:

  • Sphenoid wing meningiomas (SWMs) are challenging intracranial tumors, accounting for 18% of brain masses.
  • Peritumoral brain edema (PTBE) is frequently associated with SWMs and linked to surgical complications and recurrence.
  • Understanding the prognostic role of PTBE is crucial for optimizing surgical outcomes.

Purpose of the Study:

  • To evaluate the surgical outcomes of sphenoid wing meningiomas.
  • To assess the impact of peritumoral brain edema (PTBE) as a prognostic factor in surgically treated SWM patients.
  • To analyze the relationship between PTBE and postoperative complications, quality of life, recurrence, and mortality.

Main Methods:

  • Retrospective analysis of 65 patients with SWM treated microsurgically between 2007 and 2020.
  • Evaluation of clinical outcomes including neurological deficit, Karnofsky Performance Status (KPS), recurrence, and mortality.
  • Assessment of peritumoral brain edema using an edema index (EI); EI > 1 indicated present edema.

Main Results:

  • Total resection (Simpson I-II) was achieved in 64.6% of patients.
  • Postoperative complications included vision impairment, motor weakness, third nerve palsy, bleeding, edema, and MCA infarct.
  • Peritumoral brain edema (PTBE) was identified as a significant risk factor for immediate surgical complications and negatively affected KPS in the short term (p=0.011).

Conclusions:

  • Peritumoral brain edema (PTBE) is a critical factor influencing early surgical outcomes and complications in sphenoid wing meningioma patients.
  • PTBE is associated with a decline in quality of life in the early postoperative period.
  • While PTBE impacts short-term outcomes, its long-term prognostic significance requires further investigation.
Keywords:
MortalityPeritumoral brain edemaQuality of lifeSphenoid wing meningioma

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