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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Energy-Efficient, On-Demand Activation of Biosensor Arrays for Long-Term Continuous Health Monitoring.

Jonathan Lundquist¹, Benjamin Horstmann¹, Dmitry Pestov²

¹Department of Electrical and Computer Engineering, College of Engineering, Virginia Commonwealth University, 907 Floyd Ave, Richmond, VA 23284, USA.

|May 28, 2022

Summary

This study introduces a novel method to extend the life of wearable biosensors for continuous glucose monitoring. By using a current pulse to decompose protective membranes, sensor arrays can be activated on demand, reducing costs and improving patient care.

Keywords:

biosensor array continuous glucose monitoring pulse current activation

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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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Published on: September 19, 2017

Area of Science:

Biomedical Engineering
Materials Science
Sensor Technology

Background:

Wearable biosensors, especially for glucose detection, suffer from limited operational lifetimes due to biodegradation and fouling.
Frequent sensor replacement increases costs and patient discomfort.
Current sensor designs necessitate continuous exposure to bioanalyte environments.

Purpose of the Study:

To demonstrate a method for increasing the operational longevity of wearable biosensor arrays.
To reduce the cost and improve patient outcomes associated with continuous health monitoring.
To enable on-demand activation of individual sensors within an array.

Main Methods:

Utilized arrays of multiple sensors with protective nitrocellulose membranes.
Developed a system using metal contacts and graphene-loaded PEDOT:PSS polymer to deliver a current pulse.
Initiated decomposition of the nitrocellulose membrane via electrical energy to expose individual sensors.

Main Results:

Successfully demonstrated the decomposition of combustible nitrocellulose membranes using a current pulse.
Achieved membrane decomposition with as little as 68 mJ of electrical energy.
Confirmed consistent transfer of sub-1 µm nitrocellulose membranes onto polydimethylsiloxane (PDMS) wells.

Conclusions:

The proposed on-demand activation strategy significantly enhances the operational longevity of biosensor arrays.
This approach offers a cost-effective solution for continuous health monitoring.
The technology has the potential to improve patient outcomes by reducing the need for frequent sensor replacement.