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Published on: September 10, 2014
Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
Jennyffer Souza1, Rodrigo Augusto da Silva2, Débora da Luz Scheffer1,3
1Department of Biochemistry, Laboratory of Bioenergetics and Oxidative Stress-LABOX, Federal University of Santa Catarina, Florianópolis 88037-100, Brazil.
Abstract:
Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidence indicates that the regular practice of physical exercise increases cellular antioxidant defenses by activating NRF2 signaling. This manuscript reviewed classic and ongoing research on the beneficial effects of exercise on the antioxidant system in both the brain and skeletal muscle.
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