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Updated: Sep 21, 2025

Determination of Mitochondrial Respiration and Glycolysis in Ex Vivo Retinal Tissue Samples
Published on: August 4, 2021
Metabolism Dysregulation in Retinal Diseases and Related Therapies
Yingying Chen1,2, Nathan J Coorey3, Meixia Zhang1,4
1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610017, China.
Abstract:
The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have.
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