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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Sep 21, 2025

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes
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Advances in Recapitulating Alzheimer's Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro

Md Fayad Hasan1, Eugenia Trushina1,2

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Brain Sciences
|May 28, 2022
PubMed
Summary
This summary is machine-generated.

Human induced pluripotent stem cells (HiPSCs) create advanced Alzheimer's disease (AD) models. These patient-derived models offer new avenues for understanding AD mechanisms and accelerating drug discovery for this neurodegenerative disorder.

Keywords:
3D cultureAlzheimer’s diseasebiofabricationdisease modelinghuman induced pluripotent stem cell (HiPSC)microfluidicsorganoidspheroidstem cells

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Area of Science:

  • Neurodegenerative diseases
  • Stem cell biology
  • Drug discovery

Background:

  • Alzheimer's disease (AD) is a leading cause of death, with current treatments only managing symptoms.
  • Existing animal models fail to fully capture the complexity of sporadic late-onset AD.
  • Recent research highlights the intricate neurobiology of AD, necessitating novel modeling approaches.

Purpose of the Study:

  • To review the development of human induced pluripotent stem cell (HiPSC)-based models for Alzheimer's disease research.
  • To explore the application of these advanced models in understanding AD mechanisms.
  • To highlight the utility of HiPSC models in drug discovery for Alzheimer's disease.

Main Methods:

  • Utilizing patient-derived human induced pluripotent stem cells (HiPSCs).
  • Developing brain-like microenvironments to model AD.
  • Employing HiPSC-based models for high-throughput drug screening.

Main Results:

  • HiPSC models recapitulate patient-specific genetic backgrounds.
  • These models exhibit clinically relevant Alzheimer's disease phenotypes.
  • HiPSC-based systems enable cost-effective and efficient drug discovery studies.

Conclusions:

  • HiPSC technology provides a powerful platform for modeling Alzheimer's disease.
  • Patient-derived stem cell models are crucial for advancing AD research and therapeutic development.
  • HiPSC models are instrumental in identifying novel drug targets and treatments for Alzheimer's disease.