A study of some factors affecting the dissolution rate enhancement of sulfamethoxazole by crystallization in aqueous...

Effects of crystallization of poorly water soluble sulfamethoxazole in aqueous surfactants solutions on its in vitro dissolution rates were investigated. Marked enhancement was observed. Infrared spectra studies on the prepared crystals indicated polymorphic changes. Some factors affecting the dissolution rate enhancement of crystals prepared in the presence of surfactant namely, the type of the dissolution apparatus, the method of preparation, the type of surfactant, the concentration of surfactant, and washing and soaking of the crystals, were studied. The results of the different effects and possible mechanisms involved are discussed.