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Related Experiment Video

Updated: Sep 21, 2025

Assessing Activity-based Anorexia in Mice

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

The BDNF Val66Met Polymorphism Does Not Increase Susceptibility to Activity-Based Anorexia in Rats.

Carla L Pietrucci¹, Laura K Milton^1,2, Erika Greaves¹

¹Department of Physiology, Monash University, Clayton 3800, Australia.

|May 28, 2022

Summary

This summary is machine-generated.

The brain-derived neurotrophic factor (BDNF) Val68Met polymorphism in rats does not affect susceptibility to activity-based anorexia or feeding behaviors. These findings suggest species-specific differences in stress reactivity may explain previous results in mice.

Keywords:

66Met activity-based anorexia animal models anorexia nervosa brain-derived neurotrophic factor feeding

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Last Updated: Sep 21, 2025

Assessing Activity-based Anorexia in Mice

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Published on: May 14, 2018

Fat Preference: A Novel Model of Eating Behavior in Rats

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Published on: June 27, 2014

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Area of Science:

Neuroscience
Genetics
Animal Models

Background:

Brain-derived neurotrophic factor (BDNF) plays a role in feeding regulation and is reduced in anorexia nervosa (AN).
The BDNF Val66Met polymorphism is linked to poorer AN outcomes and promotes anorectic behavior in mice.
Activity-based anorexia (ABA) is a key animal model for AN, typically studied in rats.

Purpose of the Study:

To investigate the impact of the BDNF Val68Met polymorphism on ABA outcomes in rats.
To explore the role of this polymorphism in feeding behavior, food choice, sucrose preference, and energy expenditure.

Main Methods:

Development of a novel rat model with the BDNF Val68Met allelic variation.
Assessment of ABA susceptibility and feeding parameters in these rats.
Evaluation of food choice, sucrose preference, and energy expenditure.

Main Results:

The BDNF Val68Met polymorphism did not influence susceptibility to activity-based anorexia in rats.
No significant effects of the polymorphism were observed on feeding behavior, food choice, sucrose preference, or energy expenditure.
Results contrast with previous findings in mouse models.

Conclusions:

The BDNF Val68Met polymorphism does not appear to play a significant role in the rat model of ABA or related feeding behaviors.
Discrepancies with mouse studies may stem from species-specific differences in stress reactivity.
Further research is needed to elucidate the role of BDNF and its polymorphisms in anorexia nervosa across species.