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Updated: Sep 21, 2025
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Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
Published on: November 5, 2020
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Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool
Heidelinde Sammallahti1,2, Virinder Kaur Sarhadi3, Arto Kokkola2
1Department of Pathology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Biomolecules
|May 28, 2022
Summary
Early detection of pancreatic cancer (PC) is crucial. Analyzing oncogenomic alterations and gut microbiota in stool offers a promising, non-invasive approach for developing effective PC screening tools.
Area of Science:
- Oncology
- Genomics
- Gastroenterology
Background:
- Pancreatic cancer (PC) is highly aggressive with poor survival rates.
- Early diagnosis through non-invasive screening is essential for improving patient outcomes.
- Tumor-derived materials in body fluids offer potential for early detection.
Purpose of the Study:
- To explore oncogenomic alterations in pancreatic cancer tissue.
- To investigate the role of gut microbiota in PC.
- To review the potential of stool-based genomic and microbiota markers for PC screening.
Main Methods:
- Review of oncogenomic changes in PC tissue (chromosomal aberrations, gene mutations, epigenetic alterations, non-coding RNA).
- Exploration of the association between gut microbiota and PC.
- Analysis of genomic alterations found in stool samples from PC patients.
Main Results:
- Various oncogenomic alterations are identified in PC.
- Gut microbiota may play a role in PC development and progression.
- Genomic alterations are detectable in the stool of PC patients.
Conclusions:
- Stool analysis presents a convenient and cost-effective method for PC screening.
- Combining genomic markers with microbiota analysis may enhance screening tool efficacy.
- Further research is needed to overcome challenges in developing reliable stool-based PC screening tools.
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