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Loricrin at the Boundary between Inside and Outside
Yosuke Ishitsuka1, Dennis R Roop2
1Department of Dermatology Integrated Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.
Biomolecules
|May 28, 2022
Summary
Loricrin (LOR) protein is key to skin barrier formation in terrestrial animals, organizing epidermal structure and protecting against oxidative stress. This review explores LOR
Area of Science:
- Dermatology and Cell Biology: Focuses on epidermal differentiation and skin barrier function.
Background:
- Cornification is a specialized cell-death process crucial for terrestrial amniotes.
- Loricrin (LOR) is identified as a significant effector protein in cornification.
- LOR contributes to epidermal maturation and protection against oxidative damage.
Purpose of the Study:
- To classify ichthyosiform dermatoses based on functional mechanisms.
- To review the role of the Loricrin (LOR) and NRF2 pathway in skin homeostasis.
- To explore the immunomodulatory functions of LOR.
Main Methods:
- Review of existing literature on cornification mechanisms.
- Analysis of the Kelch-like erythroid cell-derived protein with the cap "n" collar homology-associated protein 1/nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway.
- Examination of LOR's role in keratinocyte-leukocyte interactions.
Main Results:
- Loricrin (LOR) organizes epidermal structure via covalent cross-linkages, enhancing protection.
- The LOR and NRF2 pathways are critical for epidermal xenobiotic metabolism.
- Loricrin (LOR) exhibits immunomodulatory functions in the epidermis.
Conclusions:
- A functional classification of ichthyosiform dermatoses is proposed.
- The interplay between LOR, NRF2, and immune cells is vital for skin health.
- Understanding LOR's mechanisms offers new insights into epidermal diseases.
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