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Loricrin at the Boundary between Inside and Outside.

Yosuke Ishitsuka1, Dennis R Roop2

  • 1Department of Dermatology Integrated Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.

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|May 28, 2022
PubMed
Summary
This summary is machine-generated.

Loricrin (LOR) protein is key to skin barrier formation in terrestrial animals, organizing epidermal structure and protecting against oxidative stress. This review explores LOR

Keywords:
Langerhans cellTGF-βichthyosisloricrinoxidationreduction

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Area of Science:

  • Dermatology and Cell Biology: Focuses on epidermal differentiation and skin barrier function.

Background:

  • Cornification is a specialized cell-death process crucial for terrestrial amniotes.
  • Loricrin (LOR) is identified as a significant effector protein in cornification.
  • LOR contributes to epidermal maturation and protection against oxidative damage.

Purpose of the Study:

  • To classify ichthyosiform dermatoses based on functional mechanisms.
  • To review the role of the Loricrin (LOR) and NRF2 pathway in skin homeostasis.
  • To explore the immunomodulatory functions of LOR.

Main Methods:

  • Review of existing literature on cornification mechanisms.
  • Analysis of the Kelch-like erythroid cell-derived protein with the cap "n" collar homology-associated protein 1/nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway.
  • Examination of LOR's role in keratinocyte-leukocyte interactions.

Main Results:

  • Loricrin (LOR) organizes epidermal structure via covalent cross-linkages, enhancing protection.
  • The LOR and NRF2 pathways are critical for epidermal xenobiotic metabolism.
  • Loricrin (LOR) exhibits immunomodulatory functions in the epidermis.

Conclusions:

  • A functional classification of ichthyosiform dermatoses is proposed.
  • The interplay between LOR, NRF2, and immune cells is vital for skin health.
  • Understanding LOR's mechanisms offers new insights into epidermal diseases.