Related Experiment Video
Updated: Sep 21, 2025
06:50
A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
1.9K
Neuroinflammation in Post-Traumatic Stress Disorder
Dong-Hun Lee1,2, Ji-Young Lee1, Dong-Yong Hong1,2
1Department of Neurosurgery, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan 31151, Korea.
Biomedicines
|May 28, 2022
Summary
Post-traumatic stress disorder (PTSD) is linked to increased inflammation and elevated inflammatory biomarkers. This review explores PTSD
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Post-traumatic stress disorder (PTSD) is a mental health condition often linked to trauma.
- Emerging evidence suggests a significant connection between PTSD and the immune system's inflammatory response.
Purpose of the Study:
- To review the definition and characteristics of PTSD.
- To explore the association between PTSD and heightened inflammation.
- To discuss the mechanisms, potential future diseases, and treatment possibilities related to inflammation in PTSD.
Main Methods:
- Review of existing scientific literature on PTSD and inflammation.
- Analysis of studies comparing inflammatory cytokine biomarkers in PTSD patients and healthy controls.
- Examination of animal model experiments investigating the role of inflammation in PTSD.
Main Results:
- Patients with PTSD exhibit elevated levels of inflammatory cytokine biomarkers, including interleukin-1, interleukin-6, tumor necrosis factor-α, nuclear factor-κB, and C-reactive protein, compared to healthy individuals.
- Animal models mimicking PTSD symptoms indicate inflammation's involvement in the disorder's development and progression.
Conclusions:
- Inflammation plays a crucial role in the pathogenesis and pathophysiology of PTSD.
- Understanding the link between inflammation and PTSD opens avenues for novel therapeutic strategies, including anti-inflammatory treatments.
Keywords:
animal modelsbehavior testdamage-associated molecular patternshypothalamic-pituitary-adrenal axisinflammationkynurenineneuroinflammationpost-traumatic stress disorderserotonintryptophanMore Related Videos
08:29Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
Published on: October 10, 2012
16.2K
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.3K
Related Concept Videos
01:27Post-traumatic Stress Disorder
129
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
129
01:27Psychoneuroimmunology: Cardiovascular Disease
84
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
84
01:20Traumatic Memory
263
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
263
01:27Introduction to Stress and Lifestyle
224
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
224
01:30Stress and Mental Health
224
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
224
01:15Neurogenesis and Regeneration of Nervous Tissue
1.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.1K