Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
Abdallah Mohammad Ibrahim1, Lalita Chauhan2, Aditi Bhardwaj3
1Department of Fundamentals of Nursing, College of Nursing, Imam Abdul Rahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Biomedicines
|May 28, 2022
Summary
Brain-derived neurotrophic factor (BDNF) is crucial for nerve health and memory. Higher BDNF levels are linked to a reduced risk of neurodegenerative diseases like Alzheimer's and Parkinson's.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Neurodegenerative diseases present a global challenge, causing significant disability.
- Brain-derived neurotrophic factor (BDNF) is vital for neuronal development, function, and survival.
- BDNF plays key roles in synaptic plasticity and memory formation, and is linked to Alzheimer's and Parkinson's disease.
Purpose of the Study:
- To review current research on the relationship between BDNF levels and neurodegenerative diseases.
- To elucidate the neuroprotective mechanisms of BDNF.
Main Methods:
- Literature review of studies investigating BDNF in neurodegenerative disease models and human cohorts.
- Analysis of research on BDNF signaling pathways, particularly involving tropomyosin receptor kinase B (TrKB).
Main Results:
- Reduced BDNF levels are associated with impaired neuronal function and survival.
- Decreased BDNF is implicated in the pathology of major neurodegenerative disorders.
- Elevated BDNF levels correlate with a lower incidence of neurodegenerative conditions.
Conclusions:
- BDNF is a critical factor in maintaining neurological health.
- Modulating BDNF levels may offer a therapeutic strategy for neurodegenerative diseases.
- Further research into BDNF's role can inform the development of novel treatments.
Keywords:
Alzheimer’s diseaseParkinson’s diseasebrain-derived neurotrophic factorneurodegenerative disorderstropomyosin receptor kinase BMore Related Videos
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