Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma.

ChemMedChem·2025

Same author

Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell function.

Cell death discovery·2025

Same author

Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications.

Molecular biology reports·2023

Same author

Histone deacetylase-based dual targeted inhibition in multiple myeloma.

Medicinal research reviews·2023

Same author

Entinostat-Bortezomib Hybrids against Multiple Myeloma.

Molecules (Basel, Switzerland)·2023

Same author

Isolation and Structure Elucidation of Compounds from <i>Sesamum alatum</i> and Their Antiproliferative Activity against Multiple Myeloma Cells.

Journal of natural products·2022

Search research articles

Related Experiment Video

Updated: Sep 21, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

The Multiple Myeloma Landscape: Epigenetics and Non-Coding RNAs.

Isabel F Coira^1,2, Rafael Rincón^1,2, Muriel Cuendet^1,2

¹School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.

|May 28, 2022

Summary

Multiple myeloma (MM) is challenging to treat. Epigenetic factors and non-coding RNAs are key to MM development, offering new therapeutic targets for better patient outcomes.

Keywords:

CRISPR-Cas long non-coding RNA microRNA multiple myeloma non-coding RNA

More Related Videos

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Related Experiment Videos

Last Updated: Sep 21, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Area of Science:

Oncohematology
Molecular Biology
Epigenetics

Background:

Multiple myeloma (MM) remains an incurable hematologic malignancy.
Advances in understanding MM molecular basis are crucial for new treatments.
Epigenetic factors and non-coding RNAs play significant roles in MM pathogenesis.

Purpose of the Study:

To review current knowledge on epigenetics in multiple myeloma.
To summarize the role of non-coding RNAs in MM pathogenesis.
To highlight novel therapeutic strategies targeting epigenetic modifications and non-coding RNAs.

Main Methods:

Literature review of recent studies on epigenetics and non-coding RNAs in MM.
Analysis of genome-wide data identifying key molecular players.
Examination of emerging therapeutic technologies like CRISPR-Cas.

Main Results:

Epigenetic factors beyond methylation and acetylation are implicated in MM.
Non-coding RNA dysregulation is a critical aspect of MM development.
CRISPR-Cas and other molecular techniques offer potential for innovative MM therapies.

Conclusions:

Epigenetics and non-coding RNAs represent promising avenues for MM research.
Targeting these molecular pathways could lead to improved treatment outcomes for MM patients.
Further investigation into these mechanisms is essential for developing effective therapies.