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SGK1 in Cancer: Biomarker and Drug Target

Jonas Cicenas1,2,3, Edita Meskinyte-Kausiliene3, Vigilijus Jukna3

  • 1Proteomics Centre, Institute of Biochemistry, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, Lithuania.

Cancers
|May 28, 2022
PubMed

Insights

Serum- and glucocorticoid-regulated kinase 1 (SGK1) impacts cancer progression by influencing cell survival and metastasis. Targeting SGK1 presents a potential therapeutic strategy for cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Serum- and glucocorticoid-regulated kinases (SGKs) are AGC family serine/threonine kinases.
  • SGK1 is upregulated in some cancers and downregulated in others.
  • SGK1 influences tumor cell survival, adhesion, invasion, motility, and epithelial-mesenchymal transition.

Purpose of the Study:

  • To review the role of SGK1 in cancer.
  • To discuss SGK1 as a potential biomarker.
  • To explore SGK1 as a therapeutic target.

Main Methods:

  • Literature review of SGK1's function in cancer.
  • Analysis of SGK1's molecular mechanisms in tumor growth.
  • Examination of SGK1's clinical relevance.

Main Results:

  • SGK1 promotes tumor growth via ion channels, transporters, and signaling pathways (e.g., β-catenin, NFκB).
  • SGK1 affects key cancer hallmarks like survival and invasiveness.
  • SGK1's expression levels vary across different cancer types.

Conclusions:

  • SGK1 plays a significant role in cancer progression.
  • SGK1 holds potential as a diagnostic biomarker.
  • Targeting SGK1 offers a promising therapeutic avenue for cancer treatment.
Keywords:
SGK1SGK1 inhibitorsbiomarkerscancerkinasesphosphorylation

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