MDACT: A New Principle of Adjunctive Cancer Treatment Using Combinations of Multiple Repurposed Drugs, with an
Richard E Kast1, Alex Alfieri2, Hazem I Assi3
1IIAIGC Study Center, Burlington, VT 05408, USA.
Cancers
|May 28, 2022
Summary
Multidrug adjunctive cancer treatment (MDACT) uses repurposed drugs to slow cancer growth by targeting multiple pathways. This approach complements existing therapies, offering new strategies for incurable cancers.
Area of Science:
- Oncology
- Pharmacology
- Cancer Therapeutics
Background:
- Current treatments for incurable cancers remain limited.
- Multidrug regimens have shown promise but require optimization.
- Repurposed non-oncology drugs offer novel therapeutic avenues.
Purpose of the Study:
- To present eight principles for effective multidrug adjunctive cancer treatment (MDACT).
- To introduce a novel MDACT regimen (gMDACT) for common cancers.
- To emphasize MDACT as an adjuvant to cytotoxic therapies.
Main Methods:
- Development of eight core principles for MDACT.
- Adaptation of existing multidrug treatment concepts (e.g., CUSP9v3).
- Design of gMDACT using six repurposed drugs targeting common cancer pathways.
Main Results:
- Eight principles for MDACT were elucidated.
- gMDACT demonstrated potential application across cholangiocarcinoma, colon adenocarcinoma, glioblastoma, and non-small-cell lung cancer.
- MDACT regimens are designed to complement, not replace, existing treatments.
Conclusions:
- MDACT offers a strategic framework for managing incurable cancers.
- Targeting multiple growth pathways with repurposed drugs is a viable strategy.
- MDACT enhances treatment efficacy when used adjunctively with cytotoxic drugs.
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