Related Experiment Video

Updated: Sep 21, 2025

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.6K

A Comprehensive Assessment of Cardiomyopathies through Cardiovascular Magnetic Resonance: Focus on the Pediatric

Francesca Baessato1,2, Cristina Romeo2, Mark G Rabbat3

  • 1Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, 80636 Munich, Germany.

Diagnostics (Basel, Switzerland)
|May 28, 2022
PubMed

Insights

Cardiomyopathies (CMPs) in children are rare but serious. Cardiovascular magnetic resonance (CMR) is a key imaging tool for diagnosing pediatric CMPs, assessing severity, and guiding treatment for better outcomes.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Medical Imaging

Background:

  • Cardiomyopathies (CMPs) are myocardial diseases impacting cardiac function, potentially leading to severe complications like heart failure and sudden cardiac death.
  • Pediatric CMPs are uncommon but associated with poorer prognoses.
  • Non-invasive cardiac imaging, alongside clinical, genetic, and ECG data, is crucial for diagnosing CMPs and identifying complications.

Purpose of the Study:

  • To review the role of advanced cardiovascular magnetic resonance (CMR) imaging in pediatric cardiomyopathies.
  • To highlight CMR's utility in diagnosing and characterizing common pediatric CMP phenotypes, including dilated, hypertrophic, and non-compacted forms.

Main Methods:

  • This review synthesizes current knowledge on cardiovascular magnetic resonance (CMR) applications in pediatric cardiomyopathies.
  • Focuses on CMR's diagnostic and prognostic capabilities compared to other imaging modalities.

Main Results:

  • Cardiovascular magnetic resonance (CMR) offers high spatial and temporal resolution, without ionizing radiation, making it a valuable tool complementary to echocardiography.
  • CMR enables in vivo myocardial tissue characterization, identifying pathological changes like fibrosis, which are critical predictors of adverse outcomes.
  • CMR aids in confirming diagnoses, providing prognostic information, and guiding therapeutic strategies for pediatric CMPs.

Conclusions:

  • Cardiovascular magnetic resonance (CMR) is a powerful imaging modality for the comprehensive evaluation of pediatric cardiomyopathies.
  • Further large-scale prospective studies are warranted to fully validate CMR's role in childhood CMP management.
  • CMR's ability to characterize myocardial tissue is essential for risk stratification and treatment planning in pediatric CMP patients.

Keywords:
cardiovascular magnetic resonancediagnostic accuracydilated cardiomyopathyhypertrophic cardiomyopathyleft ventricular non compactionprognosis

More Related Videos

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.5K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
144
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
71
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
48
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
78
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
44
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
36