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Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis

Dimitrios A Vrachatis1, Konstantinos A Papathanasiou1, Dimitrios Kazantzis1

  • 1Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Diagnostics (Basel, Switzerland)
|May 28, 2022
PubMed

Insights

Inflammatory markers, including neutrophil to lymphocyte ratio (NLR), are elevated in patients with coronary artery ectasia (CAE). This suggests inflammation plays a role in CAE development, warranting further research into this rare condition.

Area of Science:

  • Cardiology
  • Immunology
  • Inflammation Research

Background:

  • Coronary artery ectasia (CAE) is a rare condition with unclear causes.
  • Emerging evidence suggests inflammation is a key factor in CAE pathogenesis.

Purpose of the Study:

  • To investigate the association between neutrophil to lymphocyte ratio (NLR) and coronary artery ectasia (CAE).
  • To evaluate other inflammatory biomarkers in patients with CAE compared to controls.

Main Methods:

  • A systematic literature search was performed across multiple databases (MEDLINE, ClinicalTrials.gov, medRxiv, Scopus, Cochrane Library).
  • Fifty relevant studies comparing NLR and other inflammatory markers (hs-CRP, IL-6, TNF-a, RDW) between CAE patients and controls were included.
  • Meta-analysis was used to synthesize the data.

Main Results:

  • Neutrophil to lymphocyte ratio (NLR) was significantly higher in CAE patients (SMD = 0.73).
  • Other inflammatory markers including hs-CRP (SMD = 0.96), IL-6 (SMD = 2.68), TNF-a (SMD = 0.50), and RDW (SMD = 0.56) were also elevated in CAE patients.
  • All investigated inflammatory biomarkers showed higher levels in CAE patients compared to healthy controls.

Conclusions:

  • Inflammatory dysregulation is implicated in the development of coronary artery ectasia (CAE).
  • Elevated NLR and other inflammatory markers support a role for inflammation in CAE.
  • Further investigation into the inflammatory mechanisms underlying CAE is warranted.

Keywords:
biomarkerscoronary artery ectasiainflammationneutrophil lymphocyte ratio

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