Related Experiment Video
Updated: Sep 21, 2025
12:24
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
Published on: June 20, 2014
10.0K
Post-RNA (mRNA) Vaccination Myocarditis: CMR Features
Karuna M Das1, Taleb Al Mansoori1, Ali Al Shamisi2
1College of Medicine and Health Sciences, United Arab Emirates University, Sheikh Khalifa Bin Zayed Street, Asharej, Al Ain P.O. Box 17666, United Arab Emirates.
Diagnostics (Basel, Switzerland)
|May 28, 2022
Summary
Messenger RNA (mRNA) vaccines for COVID-19 may rarely lead to myocarditis. This case study details acute myocarditis in a 27-year-old male following his second Pfizer vaccine dose, confirmed by cardiac magnetic resonance imaging.
Area of Science:
- Cardiology
- Immunology
- Vaccinology
Background:
- Messenger RNA (mRNA) vaccines are widely used for COVID-19 prevention.
- Myocarditis, inflammation of the heart muscle, has been rarely reported as a potential adverse event following mRNA vaccination.
Purpose of the Study:
- To report a case of acute myocarditis in a young adult after receiving the second dose of an mRNA COVID-19 vaccine.
- To describe the clinical presentation, diagnostic findings, and cardiac magnetic resonance (CMR) characteristics of vaccine-associated myocarditis.
Main Methods:
- Case report of a 27-year-old male presenting with chest pain post-vaccination.
- Utilized electrocardiography (ECG), laboratory tests (troponin), echocardiography, coronary angiography, and cardiac magnetic resonance (CMR) for diagnosis.
- CMR included late gadolinium enhancement (LGE), native T1 and T2 mapping, and myocardial strain analysis.
Main Results:
- The patient developed chest pain 3 days after the second Pfizer vaccine dose.
- ECG showed non-specific ST-T changes; troponin levels were elevated.
- CMR revealed LGE in the left ventricle, reduced native T1/T2 values, and impaired myocardial strain, consistent with acute myocarditis.
Conclusions:
- Acute myocarditis is a potential, though rare, complication following mRNA COVID-19 vaccination.
- Cardiac magnetic resonance imaging is crucial for diagnosing and characterizing vaccine-associated myocarditis.
- Early diagnosis and management are important for patients presenting with symptoms suggestive of myocarditis post-vaccination.
Related Concept Videos
01:27Myocarditis II: Clinical Features and Diagnostic Tests
34
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
34
01:14Myocarditis III: Medical Management
24
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
24
01:21Imaging Studies for Cardiovascular System IV: CMRI
144
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
144
01:23Mitral Regurgitation II: Clinical Features and Diagnostic Tests
62
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
62
01:21Myocarditis I: Introduction
42
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
42
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
48
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
48