Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Organization of the Brain01:30

Organization of the Brain

1.2K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
1.2K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.7K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.7K
Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

6.7K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
6.7K
Neural Regulation01:37

Neural Regulation

40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

21.0K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
21.0K
Human Genetics01:28

Human Genetics

748
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
748

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MICU2 controls mitochondrial calcium signaling and migration in neurons during development.

Cell reports·2025
Same author

Feasibility of a Smart Label-Enabled Remote Therapeutic Monitoring Intervention to Support Cyclin-Dependent Kinase 4/6 Inhibitor Adherence in Breast Cancer Care.

JCO clinical cancer informatics·2025
Same author

Maternal Exposure to Carbamazepine at Environmentally Relevant Concentrations Causes Growth Delay in Mouse Embryos.

ACS omega·2025
Same author

Neural Progenitors as a Novel Pathogenic Mechanism in Microcephaly.

bioRxiv : the preprint server for biology·2025
Same author

Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease.

Nature communications·2025
Same author

Examining the NEUROG2 lineage and associated gene expression in human cortical organoids.

Development (Cambridge, England)·2024
Same journal

RETRACTED: Bakshi et al. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. <i>Cells</i> 2022, <i>11</i>, 1502.

Cells·2026
Same journal

Correction: Verde et al. Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses. <i>Cells</i> 2025, <i>14</i>, 680.

Cells·2026
Same journal

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cells·2026
Same journal

IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.

Cells·2026
Same journal

Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria.

Cells·2026
Same journal

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026
See all related articles

Related Experiment Video

Updated: Sep 21, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Brain Organization and Human Diseases.

Tamar Sapir1, Dalit Sela-Donenfeld2, Maayan Karlinski1

  • 1Departments of Molecular Genetics and Molecular Neuroscience, Weizmann Institute of Science, Rehovot 7610001, Israel.

Cells
|May 28, 2022
PubMed
Summary
This summary is machine-generated.

This study proposes a developmental approach to understand how the human brain's cortex forms and how common malformations arise. Examining the developing cortex offers insights into brain structure and function.

Keywords:
cortical developmentforebrainholoprosencephalylissencephalyneuronal migrationsignaling factorstelencephalon

More Related Videos

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

49.2K
Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.1K

Related Experiment Videos

Last Updated: Sep 21, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K
Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

49.2K
Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.1K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Human Anatomy

Background:

  • The cerebral cortex is a complex, organized structure crucial for brain function.
  • Cortical development originates from the caudal neural tube.
  • Spatial organization during development dictates future functional areas.

Purpose of the Study:

  • To propose a developmental perspective for understanding cortical malformations.
  • To elucidate the etiology and manifestation of common brain malformations.
  • To link developmental processes to observed cortical abnormalities.

Main Methods:

  • Review of developmental neurobiology principles.
  • Analysis of spatial organization in neural tube development.
  • Correlation of developmental events with known cortical malformations.

Main Results:

  • A developmental framework can explain the origins of cortical malformations.
  • Understanding early organization reveals mechanisms of later functional arealization.
  • Developmental etiology is key to understanding malformation manifestation.

Conclusions:

  • A developmental perspective is essential for comprehending cortical malformations.
  • The study provides a framework for future research into brain development and disorders.
  • This approach aids in understanding the link between early development and brain structure abnormalities.