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Updated: Sep 21, 2025

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
The Role of Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer
Vilma Maldonado1, Jorge Melendez-Zajgla2
1Cancer Functional Genomics Laboratory, Instituto Nacional de Medicina Genomica, Periférico Sur No. 4809, Tlalpan, Mexico City 14610, Mexico.
Abstract:
Breast cancer is the leading cause of cancer-related deaths in women worldwide. In the United States, even with earlier diagnosis and treatment improvements, the decline in mortality has stagnated in recent years. More research is needed to provide better diagnostic, prognostic, and therapeutic tools for these patients. Long non-coding RNAs are newly described molecules that have extensive roles in breast cancer. Emerging reports have shown that there is a strong link between these RNAs and the hypoxic response of breast cancer cells, which may be an important factor for enhanced tumoral progression. In this review, we summarize the role of hypoxia-associated lncRNAs in the classic cancer hallmarks, describing their effects on the upstream and downstream hypoxia signaling pathway and the use of them as diagnostic and prognostic tools.
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