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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

206
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
206
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

409
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
409
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

434
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
434
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

351
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
351
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

250
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
250
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

227
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
227

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Related Experiment Video

Updated: Sep 21, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Next-Generation Probiotics for Inflammatory Bowel Disease.

Marcella Pesce1, Luisa Seguella2, Alessandro Del Re2

  • 1Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.

International Journal of Molecular Sciences
|May 28, 2022
PubMed
Summary

Engineered probiotics offer a novel therapeutic strategy for intestinal inflammatory disease (IBD). These genetically modified bacteria can deliver therapeutic molecules directly to the gut, presenting a promising alternative to conventional treatments with significant side effects.

Keywords:
bioengineeringbiosensorsbiotherapeuticsinflammatory bowel diseaseprobiotics

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Biotechnology

Background:

  • Current treatments for intestinal inflammatory disease (IBD), including corticosteroids and immunosuppressants, carry significant side effects and risks of long-term complications.
  • A substantial number of patients with IBD exhibit dependence on these conventional therapies, highlighting the need for safer and more effective treatment options.

Purpose of the Study:

  • To review the advancements in bacterial engineering for therapeutic applications.
  • To explore the potential of genetically modified probiotics as a novel biotechnological approach for treating IBD.

Main Methods:

  • This review synthesizes current research on bacterial engineering techniques.
  • It examines the mechanisms by which engineered probiotics can deliver therapeutic molecules to the intestinal environment.

Main Results:

  • Genetically modified bacteria can be designed to release specific therapeutic molecules within the intestine.
  • Engineered probiotics demonstrate potential as a new class of therapies for managing IBD.

Conclusions:

  • Engineered probiotics represent a promising frontier in IBD treatment, offering a targeted and potentially safer therapeutic strategy.
  • Further research and development in bacterial engineering could lead to viable biotechnological solutions for IBD management.