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Comparison Benefit between Hydrogen Peroxide and Adrenaline in Tonsillectomy: A Randomized Controlled Study.

Cheng-Yu Hsieh1, Chuan-Jen Hsu1,2, Hung-Pin Wu1,2

  • 1Department of Otolaryngology, Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427, Taiwan.

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Summary

Hydrogen peroxide significantly reduces operation time and blood loss during tonsillectomy compared to adrenaline. This topical hemostasis agent offers an effective option for bleeding control in the procedure.

Keywords:
adrenalineblood losshydrogen peroxidetonsillectomy

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Area of Science:

  • Otolaryngology
  • Surgical Innovation
  • Hemostasis

Background:

  • Tonsillectomy is a common surgical procedure.
  • Effective hemostasis is crucial for minimizing complications.
  • Topical agents are frequently used for bleeding control.

Purpose of the Study:

  • To compare the efficacy of hydrogen peroxide and adrenaline as topical hemostatic agents in tonsillectomy.
  • To evaluate their impact on operation time, blood loss, and postoperative pain.

Main Methods:

  • Prospective, randomized, blinded study involving 60 patients undergoing tonsillectomy.
  • Each patient received hydrogen peroxide on one tonsillar fossa and adrenaline on the other.
  • Outcomes measured included operation time, intraoperative blood loss, and postoperative pain (VAS scores).

Main Results:

  • Hydrogen peroxide group showed significantly lower intraoperative blood loss (p=0.0) and median operation time (p=0.019).
  • Postoperative pain scores (VAS) were significantly higher in the hydrogen peroxide group (p=0.001).
  • No significant difference in hemorrhage events was mentioned.

Conclusions:

  • Topical hydrogen peroxide effectively decreases operation time and intraoperative blood loss in tonsillectomy.
  • Hydrogen peroxide is a viable routine hemostatic agent for bleeding control during tonsillectomy.
  • Further research may explore strategies to mitigate increased postoperative pain.