Ozone in Patients with Periodontitis: A Clinical and Microbiological Study

Area of Science:

• Periodontology
• Biomedical Engineering
• Microbiology

Background:

• Periodontitis is a prevalent inflammatory condition affecting tooth-supporting structures.
• Mechanical therapy is the cornerstone of periodontitis treatment, but adjuncts are explored for enhanced outcomes.

Purpose of the Study:

• To evaluate the efficacy of ozone therapy as an adjunct to mechanical therapy in patients with generalized periodontitis.
• To assess the impact of gaseous ozone on clinical parameters and subgingival microbiota.

Main Methods:

• A split-mouth study design was employed with 32 generalized periodontitis patients.
• Four quadrants per patient received either gaseous ozone or air treatment over four sessions.
• Clinical variables included gingival index, clinical attachment loss, mobility (Miller's index), and visual analog scale (VAS).
• Qualitative analysis of subgingival microorganisms was performed.

Main Results:

• Ozone therapy resulted in statistically significant reductions in gingival index and clinical attachment loss (p < 0.0001).
• Significant improvements in tooth mobility (70-86%) and VAS scores were observed in ozone-treated quadrants (p < 0.0001).
• Qualitative analysis revealed significant differences in subgingival flora composition (p < 0.0001).

Conclusions:

• Ozone therapy is an effective adjunct to mechanical therapy for generalized chronic periodontitis.
• The treatment demonstrated significant clinical benefits and was well-tolerated by patients.
• Ozone therapy positively influences the clinical parameters and microbial profile in periodontitis.