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Published on: October 25, 2018
The Present and Future of Allergen Immunotherapy in Personalized Medicine
Erminia Ridolo1, Cristoforo Incorvaia1, Enrico Heffler2,3
1Allergy and Clinical Immunology, Medicine and Surgery Department, University of Parma, 43121 Parma, Italy.
Abstract:
Allergic diseases are particularly suitable for personalized medicine, because they meet the needs for therapeutic success, which include a known molecular mechanism of the disease, a diagnostic tool for that disease and a treatment that blocks this mechanism. A range of tools is available for personalized allergy diagnosis, including molecular diagnostics, treatable traits and omics (i.e., proteomics, epigenomics, metabolomics, transcriptomics and breathomics), to predict patient response to therapies, detect biomarkers and mediators and assess disease control status. Such tools enhance allergen immunotherapy. Higher diagnostic accuracy results in a significant increase (based on a greater performance achieved with personalized treatment) in efficacy, further increasing the known and unique characteristics of a treatment designed to work on allergy causes.
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