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Microfluidics Technology in SARS-CoV-2 Diagnosis and Beyond: A Systematic Review
Mohd Raeed Jamiruddin1, Bushra Ayat Meghla2, Dewan Zubaer Islam2
1Department of Pharmacy, BRAC University, Dhaka 1212, Bangladesh.
Life (Basel, Switzerland)
|May 28, 2022
Summary
Microfluidic diagnostic kits combined with various detection methods offer rapid, scalable, and sensitive detection of SARS-CoV-2 antibodies, antigens, and nucleic acids. These integrated devices enhance infection detection rates and improve global health services.
Area of Science:
- Biomedical Engineering
- Diagnostic Technologies
- Infectious Disease Research
Background:
- The COVID-19 pandemic accelerated the need for advanced diagnostic solutions.
- Microfluidic technologies have emerged as key innovations for rapid, scalable, and sensitive diagnostics.
- Integrating microfluidics with diverse detection techniques enables effective SARS-CoV-2 detection.
Purpose of the Study:
- To review microfluidic-based diagnostic kits for SARS-CoV-2 detection.
- To explore the amalgamation of microfluidics with various detection techniques.
- To assess the global availability and impact of these innovative diagnostic tools.
Main Methods:
- Systematic literature search across PubMed, ScienceDirect, and Google Scholar.
- Analysis of 1,164 articles identified through keywords: microfluidics, diagnostics, and SARS-CoV-2.
- Categorization of devices based on materials, fluid manipulation, and detection techniques.
Main Results:
- Polymer materials like PDMS and PMMA are commonly used in microfluidic devices.
- Centrifugal force is the primary fluid manipulation technique, followed by electrochemical pumping, capillary action, and isotachophoresis.
- Detection methods vary by target: spectrometers for antibodies, electrochemical for antigens, and fluorescence for nucleic acids.
- Device sensitivity and specificity are influenced by the interplay of fluid manipulation and detection techniques.
- Most devices are integrated and simple, facilitating deployment in diverse settings.
Conclusions:
- Microfluidic devices integrated with detection systems offer simplified deployment and enhanced infection detection capabilities.
- These technologies play a significant role in improving global health services through accessible diagnostics.
- Continued innovation in microfluidics and detection methods promises further advancements in infectious disease diagnostics.
