All-Solid-State Potentiometric Platforms Modified with a Multi-Walled Carbon Nanotubes for Fluoxetine Determination

Area of Science:

• Electroanalytical Chemistry
• Chemical Sensors
• Pharmaceutical Analysis

Background:

• Fluoxetine (FLX) is a widely used antidepressant.
• Accurate and rapid methods for FLX quantification are crucial for therapeutic drug monitoring and quality control.
• Existing analytical methods may be time-consuming or expensive.

Purpose of the Study:

• To design and characterize novel, cost-effective screen-printed potentiometric platforms for Fluoxetine (FLX) determination.
• To develop a simple, fast, and accurate analytical tool for FLX assessment.
• To evaluate the potential for large-scale manufacturing of these sensors.

Main Methods:

• Development of screen-printed potentiometric sensors integrating FLX sensor and Ag/AgCl reference electrode.
• Utilized neutral carriers (ionophores I, II, III), MWCNTs, and NaTFPB in a PVC matrix.
• Characterization included potentiometric response, detection limits, and interfacial capacitance measurements using reverse-current chronopotentiometry.
• Validation by comparison with High-Performance Liquid Chromatography (HPLC) and recovery studies in serum samples.

Main Results:

• Sensors exhibited near-Nernstian potentiometric responses with slopes ranging from 56.2 to 64.4 mV/decade.
• Detection limits achieved were as low as 2.0 × 10⁻⁷ M for ionophore III.
• Successful determination of FLX in pharmaceutical dosage forms and spiked serum samples.
• High recovery values indicated accurate quantification.

Conclusions:

• The developed screen-printed potentiometric platforms are effective for simple, fast, and accurate FLX assessment.
• These platforms offer a portable, rapid, disposable, and cost-effective analytical tool.
• The technology shows potential for large-scale manufacturability and practical application in drug analysis.