Vitamin D3 Serum Levels in Periodontitis Patients: A Case-Control Study

Area of Science:

• Oral Health
• Endocrinology
• Immunology

Background:

• Periodontitis involves inflammation leading to tooth tissue loss, influenced by bacterial dysbiosis and host response.
• Vitamin D3 is crucial for tissue homeostasis; its deficiency may negatively impact periodontitis progression and treatment.
• Understanding the relationship between vitamin D3 levels and periodontitis is vital for effective management.

Purpose of the Study:

• To compare serum vitamin D3 levels in periodontitis patients versus healthy controls.
• To investigate the correlation between vitamin D3 status and the severity of periodontitis.
• To assess the clinical implications of vitamin D3 levels in periodontal disease.

Main Methods:

• A cohort of 100 healthy adults (50 with periodontitis, 50 healthy controls) was recruited.
• Periodontal clinical parameters and radiographic data were collected.
• Serum 25-hydroxy vitamin D (25(OH)D) levels were measured using a standardized test.

Main Results:

• Periodontitis patients exhibited significantly lower mean serum vitamin D3 levels (31.34 ± 5.62) than healthy subjects (39.64 ± 8.77).
• Vitamin D3 deficiency correlated with increased disease stage, grade, clinical attachment loss, and bone loss.
• A statistically significant difference was observed between the two groups.

Conclusions:

• Lower vitamin D3 serum levels are associated with periodontitis.
• Vitamin D3 deficiency is linked to more severe periodontal disease indicators.
• Regular monitoring and potential supplementation of vitamin D3 may be beneficial for periodontitis patients.