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The Association between Iron-Deficiency Anemia (IDA) and Septic Arthritis (SA): The Real-World Data.
Cheng-Hung Chiang1, Cheng-Yen Li2, Kai-Chieh Hu3
1Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404, Taiwan.
Medicina (Kaunas, Lithuania)
|May 28, 2022
Summary
Iron-deficiency anemia (IDA) significantly increases the risk of developing septic arthritis (SA). This study found a 2.53-fold higher risk of SA in patients with IDA compared to controls.
Area of Science:
- Rheumatology
- Hematology
- Epidemiology
Background:
- Iron-deficiency anemia (IDA) is linked to increased susceptibility to infections and musculoskeletal issues.
- Septic arthritis (SA) is a serious musculoskeletal infection requiring prompt diagnosis and treatment.
Purpose of the Study:
- To investigate the association between iron-deficiency anemia (IDA) and the risk of developing septic arthritis (SA).
Main Methods:
- A longitudinal cohort study was conducted using the Taiwanese Longitudinal Health Insurance Database (LHID) from 2000 to 2012.
- Subjects diagnosed with IDA (ICD-9-CM: 280) formed the IDA cohort, with controls matched by age and sex (1:4 ratio).
- Follow-up occurred until SA onset (ICD-9-CM: 711.0), insurance withdrawal, or December 31, 2013.
Main Results:
- The cumulative incidence of SA was significantly higher in the IDA cohort compared to the control cohort (p < 0.0001).
- After adjusting for comorbidities, IDA patients exhibited a 2.53-fold increased risk of SA (aHR = 2.53, 95% CI = 1.89–3.38).
Conclusions:
- Iron-deficiency anemia is associated with a substantially increased risk of developing septic arthritis.
- Findings highlight the importance of considering IDA as a potential risk factor for SA.
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