The Ten-Year Risk Prediction for Cardiovascular Disease for Malaysian Adults Using the Laboratory-Based and...

Area of Science:

• Public Health
• Epidemiology
• Cardiovascular Disease Risk Prediction

Background:

• Cardiovascular disease (CVD) poses a significant global health burden.
• Risk prediction models are crucial for identifying individuals at high risk.
• The Globorisk calculator is a validated tool for CVD risk assessment.

Purpose of the Study:

• To apply the Globorisk calculator to the Malaysian adult population.
• To determine overall, sex-specific, ethnic-specific, region-specific, and state-specific 10-year CVD risk.
• To stratify CVD risk into low and high-risk categories.

Main Methods:

• Utilized data from 8253 participants of the Malaysian National Health and Morbidity Survey (NHMS 2015).
• Calculated laboratory-based and office-based 10-year CVD risk scores (fatal and fatal plus non-fatal).
• Stratified risk by sex, ethnicity, region, and state.

Main Results:

• Average 10-year risks for laboratory-based fatal CVD, laboratory-based fatal plus non-fatal CVD, and office-based fatal plus non-fatal CVD were 0.07, 0.14, and 0.11, respectively.
• Substantial differences in Globorisk scores were observed when stratified by sex, ethnicity, and state.
• Participants were categorized into low (<10%), high A (≥10%), high B (≥20%), and high C (≥30%) risk groups.

Conclusions:

• The application of the Globorisk model in Malaysia revealed significant variations in CVD risk across different demographic groups.
• Sex, ethnicity, and geographic location (state) are important factors influencing CVD risk scores in Malaysia.
• These findings underscore the importance of localized risk assessment for targeted public health interventions.