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Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging-A
Franz Wegner1, Kerstin Lüdtke-Buzug2, Sjef Cremers3
1Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, 23562 Luebeck, Germany.
Nanomaterials (Basel, Switzerland)
|May 28, 2022
Summary
Researchers developed instrument markers visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). These bimodal markers are crucial for advancing hybrid MPI/MRI systems in cardiovascular interventions.
Area of Science:
- Medical Imaging
- Nanotechnology
- Biomedical Engineering
Background:
- Hybrid imaging systems combining Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI) offer synergistic diagnostic capabilities.
- Developing effective instrument markers visible across both modalities is essential for their clinical translation, particularly in interventional procedures.
Purpose of the Study:
- To engineer and evaluate instrument markers with dual visibility in both MPI and MRI.
- To assess the performance of markers based on different magnetic nanoparticle types for hybrid imaging applications.
Main Methods:
- Fabrication of coatings using in-house KLB and commercial Bayoxide E8706 magnetic nanoparticles.
- Characterization of MPI performance using a magnetic particle spectrometer.
- Conducting imaging experiments on a preclinical MPI scanner and a 1 tesla MRI system.
- MPI image reconstruction utilizing system matrices derived from nanoparticle coatings.
Main Results:
- Bimodal instrument markers were successfully visualized in both MPI and MRI.
- MRI showed signal voids, while MPI displayed high signal intensity areas, both exceeding the actual marker size.
- MPI image reconstruction using Bayoxide E8706 system matrices yielded insufficient signal.
Conclusions:
- Instrument markers with bimodal MPI/MRI visibility are feasible and vital for monitoring cardiovascular interventions.
- The choice of magnetic nanoparticle and system matrix significantly impacts MPI performance.
- Further development is needed to optimize marker performance for robust hybrid imaging.
