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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

436
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
436
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

482
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
482
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

914
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
914
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

767
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
767
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

871
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
871
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

1.0K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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RETRACTED: Sobeh et al. A Polyphenol-Rich Fraction from <i>Eugenia uniflora</i> Exhibits Antioxidant and Hepatoprotective Activities In Vivo. <i>Pharmaceuticals</i> 2020, <i>13</i>, 84.

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Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
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Polysaccharide-Based Transdermal Drug Delivery.

Jingyuan Li1,2, Hong Xiang1, Qian Zhang1

  • 1Marine College, Shandong University, Weihai 264209, China.

Pharmaceuticals (Basel, Switzerland)
|May 28, 2022
PubMed
Summary
This summary is machine-generated.

Polysaccharides from natural sources offer safe and effective transdermal drug delivery vehicles. These materials enhance drug penetration and utilization for treating various diseases.

Keywords:
biocompatibilitybiodegradabilitydiseases therapeuticpenetrationpolysaccharidetransdermal drug delivery

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Area of Science:

  • Biomaterials Science
  • Drug Delivery
  • Nanotechnology

Background:

  • Natural polysaccharides offer advantages over synthetic polymers for drug delivery, including non-toxicity, biodegradability, and biocompatibility.
  • Polysaccharides are sourced from marine, herbal, and microbial origins.
  • Current research focuses on developing polysaccharide-based vehicles like hydrogels, films, and microneedles for transdermal applications.

Purpose of the Study:

  • To review current knowledge on polysaccharide-based transdermal drug delivery strategies.
  • To highlight the benefits of polysaccharides in enhancing transdermal drug delivery efficiency.
  • To discuss the potential of these materials in treating various diseases.

Main Methods:

  • Review of current literature on polysaccharide-based transdermal drug delivery systems.
  • Analysis of the properties of polysaccharides that facilitate skin penetration and drug delivery.
  • Examination of various polysaccharide-based delivery vehicles and their applications.

Main Results:

  • Polysaccharides improve swelling properties, mechanical strength, and tensile strength of drug delivery vehicles.
  • The charge and hydration of polysaccharides aid in overcoming the stratum corneum's resistance, promoting drug penetration.
  • Polysaccharide-based nanotechnology enhances drug utilization efficiency.

Conclusions:

  • Polysaccharide-based transdermal drug delivery systems show significant promise for efficient and safe drug administration.
  • These natural materials offer tunable properties and enhanced drug efficacy.
  • Further development of polysaccharide-based strategies is crucial for advancing transdermal therapeutics.