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Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended

Jaehyeok Lee1, Chul Haeng Lee2, Jong-Geon Lee1

  • 1BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Korea.

Pharmaceutics
|May 28, 2022
PubMed
Summary

This study developed a novel pH-modified extended-release formulation of ursodeoxycholate (UDCA) using spray-drying. The optimized formulation significantly enhanced UDCA

Keywords:
oral bioavailabilitypH-modified extended release formulationspray-drying methodursodeoxycholate (UDCA)

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