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BUB3, beyond the Simple Role of Partner.

Patrícia M A Silva1,2, Hassan Bousbaa1,3

  • 1UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), University Polytechnic Higher Education Cooperative (CESPU), Rua Central de Gandra, 4585-116 Gandra, Portugal.

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BUB3 protein is crucial for accurate cell division and preventing aneuploidy. Its dysregulation in cancer suggests it could be a potential anticancer target.

Keywords:
BUB3anticancer targetcancermitosissenescencespindle assembly checkpoint

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • BUB3 protein is essential for the spindle assembly checkpoint (SAC), ensuring accurate chromosome segregation during mitosis.
  • BUB3 also regulates microtubule attachment and telomere maintenance, with its deficiency linked to premature aging.
  • Altered BUB3 expression is observed in various human cancers, correlating with poor patient prognoses.

Purpose of the Study:

  • To review the structural and functional roles of BUB3 in mitosis.
  • To examine BUB3 expression patterns in human cancers.
  • To evaluate BUB3 as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of BUB3's function in mitosis and cancer.
  • Analysis of studies linking BUB3 expression to cancer prognosis.
  • Exploration of BUB3's potential as an anticancer target based on existing research.

Main Results:

  • BUB3 is vital for SAC activation, chromosome-spindle attachment, and telomere maintenance.
  • BUB3 gene upregulation is a frequent finding in human cancers, associated with adverse survival outcomes.
  • The multifaceted roles of BUB3 highlight its significance in both normal cell division and tumorigenesis.

Conclusions:

  • BUB3 is a critical regulator of mitosis and chromosome stability.
  • Aberrant BUB3 expression in cancer underscores its involvement in disease progression.
  • Targeting BUB3 presents a promising avenue for novel cancer therapies.