Fabrication of Polymer Microfluidics: An Overview

Area of Science:

• Microfluidics
• Materials Science
• Biotechnology

Background:

• Microfluidic platforms offer advantages like reduced reagent use and portability for analyte detection.
• Silicon was an early material for microfluidic chips, but polymers offer unique advantages for disposable devices.
• Various forces can manipulate particles within microfluidic channels.

Purpose of the Study:

• To review and classify primary fabrication techniques for polymer microfluidic devices.
• To provide a reference for researchers entering the field of polymer microfluidics.
• To highlight the suitability of polymer microfluidics for affordable, single-use applications.

Main Methods:

• Categorization of fabrication techniques into mold-based and non-mold-based approaches.
• Discussion of mold-based methods: micro-embossing, micro-injection molding, and casting.
• Discussion of non-mold-based methods: CNC micromachining, laser micromachining, and 3D printing.

Main Results:

• Identified and classified key fabrication methods for polymer microfluidics.
• Detailed specific techniques within mold-based and non-mold-based categories.
• Emphasized the versatility of polymer microfluidics fabrication.

Conclusions:

• Polymer microfluidics fabrication techniques are diverse, falling into mold-based and non-mold-based categories.
• Understanding these techniques is crucial for developing cost-effective microfluidic devices.
• This review offers a comprehensive overview for researchers and the general audience in microfluidics.