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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A

Cristiane de Freitas Paganoti1, Rafaela Alkmin da Costa1, Aris T Papageorghiou2

  • 1Divisão de Clinica Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, 255 Dr Eneas Carvalho de Aguiar Avenue, 10th floor, São Paulo 05403-000, Brazil.

Vaccines
|May 28, 2022
PubMed

Insights

COVID-19 vaccination significantly reduces severe outcomes like ICU admission, intubation, and death among pregnant and postpartum women hospitalized with severe COVID-19. These vaccines offer crucial protection for this high-risk group.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic disproportionately affects pregnant and postpartum women, placing them at higher risk for severe illness.
  • While vaccination is known to reduce infection risk, its impact on disease severity in vaccinated pregnant and postpartum individuals remains under investigation.

Purpose of the Study:

  • To evaluate the effectiveness of COVID-19 vaccination in reducing severe maternal morbidity and mortality among hospitalized pregnant and postpartum women with severe COVID-19.

Main Methods:

  • A retrospective cohort study was conducted.
  • Included 2284 pregnant and postpartum women hospitalized with severe COVID-19.
  • Compared outcomes between vaccinated and unvaccinated individuals.

Main Results:

  • Vaccinated individuals had significantly lower rates of intensive care unit (ICU) admission (p < 0.001), intubation (p < 0.001), and mortality (p < 0.001).
  • Vaccination numbers needed to prevent one ICU admission, intubation, or death were 7, 7, and 9, respectively.

Conclusions:

  • COVID-19 vaccination provides significant protective benefits against severe outcomes in hospitalized pregnant and postpartum women.
  • The findings underscore the importance of vaccination for this vulnerable population to mitigate severe COVID-19 consequences.

Keywords:
COVID-19 vaccinesintensive care unitintubationmaternal mortalitypregnancysevere acute respiratory syndrome

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