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Related Experiment Video

Updated: Sep 21, 2025

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Cryptococcal Meningoencephalitis in an Immunocompetent Patient.

Sadaf Sheikh¹, Umair Javed²

¹Department of Emergency Medicine, Sultan Qaboos University Hospital, Muscat, Oman.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|May 28, 2022

Summary

Cryptococcal meningitis (CM) is rare in immunocompetent individuals but can cause severe neurological issues. Early diagnosis and antifungal treatment are crucial for managing this opportunistic infection.

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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

Area of Science:

Infectious Diseases
Neurology
Mycology

Background:

Cryptococcal meningitis (CM) is typically an opportunistic infection in immunocompromised individuals.
However, Cryptococcus neoformans can cause severe disease in immunocompetent hosts, presenting atypical neurological symptoms.

Observation:

A 64-year-old male with no known immunosuppressive conditions presented with a year of worsening gait disturbances and lethargy.
Brain imaging revealed hydrocephalus, prompting a lumbar puncture.
Cultures confirmed Cryptococcus neoformans infection.

Findings:

The patient was diagnosed with cryptococcal meningitis despite being immunocompetent.
Successful treatment was achieved with antifungal medications.

Implications:

This case highlights the importance of considering uncommon causes of meningitis in immunocompetent patients presenting with neurological symptoms.
Emergency physicians and clinicians should be aware of atypical presentations of CM.
Prompt diagnosis and initiation of antifungal therapy are vital for favorable outcomes.