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Raised D-dimer Level among COVID-19 Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Shikha Rizal1, Bishal Raj Joshi1, Sunil Regmi2

  • 1Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar-4, Nepal.

JNMA; Journal of the Nepal Medical Association
|May 28, 2022
PubMed

Insights

Elevated serum D-dimer levels were found in 74.46% of coronavirus disease patients. This suggests D-dimer may be an early predictor for managing COVID-19 disease severity.

Area of Science:

  • Medical Research
  • Hematology
  • Infectious Diseases

Background:

  • Serum D-dimer indicates clot formation and hemostatic changes.
  • Increased D-dimer levels are linked to a prothrombotic state.
  • Identifying early predictors is crucial for managing coronavirus disease (COVID-19).

Purpose of the Study:

  • To determine the prevalence of elevated D-dimer levels in COVID-19 patients.
  • To assess D-dimer as a potential prognostic marker for COVID-19.

Main Methods:

  • A descriptive cross-sectional study involved 235 COVID-19 patients.
  • Data collected on highest recorded D-dimer values during hospitalization.
  • Statistical analysis included point estimates with 95% Confidence Intervals.

Main Results:

  • Elevated D-dimer levels were observed in 175 (74.46%) of the patients.
  • The prevalence of elevated D-dimer was higher than in global studies.
  • A majority of affected patients were male (77.71%).

Conclusions:

  • The high prevalence of elevated D-dimer in COVID-19 patients was noted.
  • Serum D-dimer may serve as an early prognostic marker.
  • This finding can aid in improving the management of coronavirus disease.
Abstract

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