EFFECT OF 20-HOUR FASTING AND LOW FAT DIET ON GHRELIN HORMONE, GLUCOSE LEVEL AND LIVER FUNCTION IN ALBINO RATS MALE.
Ahmed Zwain1, Husham Qassim Mohammed1
1UNIVERSITY OF KUFA, KUFA, IRAQ.
Summary
Fasting and low-fat diets significantly impact ghrelin hormone and glucose levels in male rats. These dietary changes also led to decreased liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
Area of Science:
- Endocrinology
- Metabolic Research
- Nutritional Science
Background:
- Ghrelin hormone plays a crucial role in appetite regulation and energy homeostasis.
- Dietary interventions like fasting and low-fat diets can influence metabolic markers.
- Understanding these effects is vital for metabolic health research.
Purpose of the Study:
- To investigate the combined effects of fasting and a low-fat diet on ghrelin hormone levels.
- To assess the impact of these dietary regimens on glucose metabolism.
- To examine the influence on key liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Main Methods:
- An experimental study involving 24 healthy, young, male albino rats.
- Rats were subjected to different dietary conditions: control, low-fat diet, fasting (20 hours), and combined fasting with a low-fat diet.
- Statistical significance was determined using one-way ANOVA.
Main Results:
- Fasting and low-fat diets significantly altered glucose levels, with variations observed between control and experimental groups.
- Ghrelin hormone levels showed significant changes, increasing with fasting in control groups but decreasing in low-fat diet groups.
- Both fasting and low-fat diet interventions led to a significant decrease in ALT and AST levels.
Conclusions:
- Fasting and low-fat diets demonstrably affect ghrelin hormone and glucose levels in male albino rats.
- Combined fasting and low-fat diet intervention resulted in decreased ALT levels.
- A 20-hour fast also led to a significant decrease in AST levels, indicating a positive effect on liver enzymes.
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