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PECULIARITIES OF THE SOURCES OF ORIGIN AND MORPHOGENESIS OF THE HUMAN MANDIBLE
Oleksandr V Tsyhykalo1, Nataliia B Kuzniak1, Serhij Yu Palis1
1BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 28, 2022
Summary
The mandible develops through intra-cartilaginous ossification, starting from cartilage ends and progressing to bone replacement. This study details the prenatal ossification timeline of the human mandible.
Area of Science:
- Developmental biology
- Human embryology
- Craniofacial development
Background:
- The prenatal development of the human mandible is crucial for craniofacial structure and function.
- Understanding the timeline of mandibular ossification provides insights into normal and abnormal development.
Purpose of the Study:
- To investigate the origin, developmental characteristics, and ossification dynamics of the human mandible during prenatal development.
- To establish a detailed timeline of mandibular ossification from the 9th to the 12th week of gestation.
Main Methods:
- Microscopic examination of 120 human embryos and fetuses (9-12 weeks gestation).
- Three-dimensional computer reconstructions of fetal heads were utilized.
- Analysis focused on the progression of osteogenesis and cartilage replacement.
Main Results:
- Mandibular ossification begins around the 8th week, with alveolar processes forming.
- By 9-10 weeks, oral and nasal cavities separate, and hyaline cartilage of the mandible's angles and rami is evident.
- Intra-cartilaginous bone formation replaces cartilage in the mandibular rami by the 12th week.
Conclusions:
- Mandibular development is characterized by intra-cartilaginous ossification, initiated at cartilage ends.
- Ossification progresses, with osseous tissue gradually replacing cartilaginous tissue in the jaws.
- The study provides a detailed temporal map of mandibular ossification during early human prenatal development.
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