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Published on: November 22, 2019
Molecular mechanisms of neuroendocrine differentiation in prostate cancer progression
Yuchen Xie1, Songyi Ning2, Jianpeng Hu3
1Affiliated Renmin Hospital of Jiangsu University, Zhenjiang First People's Hospital, Zhenjiang, 212002, China.
Background:
Rapid evolution of the therapeutic management of prostate cancer, especially in in second-generation androgen inhibitors, has increased the opportunity of transformation from prostate cancer (PCa) to neuroendocrine prostate cancer (NEPC). NEPC still lacks effective diagnostic and therapeutic interventions. Researches into the molecular characteristics of neuroendocrine differentiation is undoubtedly crucial to the discovery of new target genes for accurate diagnostic and therapeutic targets.
Purpose:
In this review, we focus on the relevant genes and molecular mechanisms that have contributed to the transformation in the progression of PCa and discuss the potential targeted molecule that might improve diagnostic accuracy and therapeutic effectiveness.
Methods:
The relevant literatures from PubMed have been reviewed for this article.
Conclusion:
Several molecular characteristics influence the progression of neuroendocrine differentiation of prostate cancer which will provide a novel sight for accurate diagnosis and target therapeutic intervention for patients with NEPC.
Insights
Neuroendocrine prostate cancer (NEPC) arises from prostate cancer (PCa) due to new treatments. Understanding NEPC
Area of Science:
- Oncology
- Molecular Biology
- Urology
Background:
- Second-generation androgen inhibitors accelerate prostate cancer (PCa) transformation to neuroendocrine prostate cancer (NEPC).
- Neuroendocrine prostate cancer (NEPC) currently lacks effective diagnostic and therapeutic strategies.
- Investigating molecular characteristics of neuroendocrine differentiation is vital for identifying new diagnostic and therapeutic targets.
Purpose of the Study:
- Review key genes and molecular mechanisms driving PCa to NEPC transformation.
- Discuss potential targeted molecules for improved NEPC diagnosis and treatment.
Main Methods:
- Comprehensive literature review of relevant studies from PubMed.
Main Results:
- Identified several molecular characteristics influencing NEPC progression.
- Highlighted the role of specific genes in neuroendocrine differentiation.
Conclusions:
- Molecular insights into NEPC progression offer new avenues for diagnosis.
- Findings pave the way for targeted therapeutic interventions in NEPC patients.
