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[Cutaneous necrotizing angiitis].

M Lessana-Leibowitch, D Trincal, L Gorin

    Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Necrotizing angiitis involves inflammatory cell infiltration and fibrinoid deposits in vessel walls, primarily affecting small dermal vessels. Cutaneous manifestations like palpable purpura can indicate systemic involvement or collagen diseases.

    Area of Science:

    • Pathology
    • Dermatology
    • Rheumatology

    Background:

    • Necrotizing angiitis is defined by specific histological findings: inflammatory infiltration with pycnotic polynuclear cells and fibrinoid deposits in vessel walls.
    • These lesions can affect small caliber vessels, including arterioles, capillaries, and post-capillary venules, particularly within the dermal microvasculature.

    Purpose of the Study:

    • To elucidate the histological characteristics and clinical spectrum of necrotizing angiitis, focusing on cutaneous manifestations.
    • To explore the association of cutaneous necrotizing angiitis with systemic diseases, including collagen diseases.

    Main Methods:

    • Histological examination of vessel wall lesions.
    • Clinical assessment of cutaneous manifestations such as palpable purpura, urticaria, livedo, and necrotic lesions.

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  • Correlation of cutaneous findings with potential systemic involvement and underlying conditions.

    • Main Results:

    • The most common clinical presentation of cutaneous necrotizing angiitis is palpable purpura.
    • Less frequent presentations include urticarial, livedoid, or necrotic skin lesions.
    • Cutaneous necrotizing angiitis can be an isolated finding or associated with systemic disease, particularly collagen vascular diseases.

    Conclusions:

    • Necrotizing angiitis encompasses a diverse group of entities and syndromes.
    • Accurate characterization requires integrating clinical, immunopathological, etiological, and biological data, as no single parameter is sufficient.
    • Cutaneous necrotizing angiitis serves as a potential indicator for broader systemic pathology.